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3,153 studies for “Roche”

A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory TreatmentCompleted
NCT07025811Phase 4Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Dry Eye Disease
United States
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)Recruiting
NCT07137598Phase 2Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Rheumatoid Arthritis
United States, Argentina, Belgium, Brazil, Denmark +6 more
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001Active Not Recruiting
NCT01760005Phase 2, Phase 3Updated Jul 27, 2026
Sponsor: Washington University School of Medicine
Alzheimers Disease · Dementia · Alzheimers Disease, Familial
United States, Argentina, Australia, Brazil, Canada +10 more
A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moderate Hemophilia A Without Factor VIII Inhibitors on Emicizumab ProphylaxisActive Not Recruiting
NCT05181618Phase 4Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Severe Hemophilia A · Moderate Hemophilia A
United States, Brazil, Canada, Germany, Hungary +7 more
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast CancerRecruiting
NCT05894239Phase 3Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Metastatic Breast Cancer
United States, Argentina, Australia, Belgium, Brazil +24 more
A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus NephritisRecruiting
NCT07598396Phase 2Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Lupus · Systemic Lupus Erythematosus · Lupus Nephritis
Brazil, Colombia, Italy, Mexico, South Africa
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular DegenerationActive Not Recruiting
NCT02286089Phase 1, Phase 2Updated Jul 27, 2026
Sponsor: Hoffmann-La Roche
Age-Related Macular Degeneration
United States, Israel
Gemcitabine, Trastuzumab, and Pertuzumab in the Treatment of Metastatic HER2-Positive Breast Cancer After Prior Trastuzumab/Pertuzumab, or Pertuzumab Based TherapyCompleted
NCT02252887Phase 2Updated Jul 24, 2026
Sponsor: Memorial Sloan Kettering Cancer Center
Metastatic HER2-Positive Breast Cancer
United States
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)Active Not Recruiting
NCT04548999Phase 3Updated Jul 24, 2026
Sponsor: Hoffmann-La Roche
Multiple Sclerosis
United States, Argentina, Belgium, Brazil, Bulgaria +17 more
Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid TumorsActive Not Recruiting
NCT03915678Phase 2Updated Jul 24, 2026
Sponsor: Institut Bergonié
Solid Tumor, Adult · Pancreatic Cancer · Virus-associated Tumors · Non Small Cell Lung Cancer
France
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease StudiesRecruiting
NCT07177352Phase 3Updated Jul 24, 2026
Sponsor: Hoffmann-La Roche
Alzheimers Disease
United States, Argentina, Australia, Brazil, Canada +9 more
An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid ArthritisRecruiting
NCT07620392Phase 2Updated Jul 24, 2026
Sponsor: Hoffmann-La Roche
Rheumatoid Arthritis
United States, Poland
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab StudyActive Not Recruiting
NCT03768063Phase 3Updated Jul 24, 2026
Sponsor: Hoffmann-La Roche
Cancer
United States, Australia, Belgium, Brazil, Bulgaria +19 more
A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent ChemoradiotherapyActive Not Recruiting
NCT04543617Phase 3Updated Jul 23, 2026
Sponsor: Hoffmann-La Roche
Esophageal Squamous Cell Carcinoma
United States, Argentina, Australia, Austria, Belgium +23 more
AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal AdenocarcinomasRecruiting
NCT07290985Phase 2Updated Jul 23, 2026
Sponsor: American Association for Cancer Research
Gastroesophageal Adenocarcinoma
United States, Canada
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple SclerosisActive Not Recruiting
NCT03523858Phase 3Updated Jul 23, 2026
Sponsor: Hoffmann-La Roche
Progressive Multiple Sclerosis (PMS)
United States, Bosnia and Herzegovina, Brazil, Canada, Colombia +19 more
An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative ColitisRecruiting
NCT07665723Phase 1Updated Jul 23, 2026
Sponsor: Hoffmann-La Roche
Active Ulcerative Colitis
United States, Germany, United Kingdom
A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7806881 in Healthy ParticipantsRecruiting
NCT07271693Phase 1Updated Jul 23, 2026
Sponsor: Hoffmann-La Roche
Healthy Volunteers
New Zealand
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With ZilebesiranRecruiting
NCT07553442Phase 2Updated Jul 23, 2026
Sponsor: Alnylam Pharmaceuticals
Hypertension
United States
Obinutuzumab for Systemic Lupus Erythematosus Pure Membranous Nephropathy: a Phase II TrialNot Yet Recruiting
NCT07721363Phase 2Updated Jul 23, 2026
Sponsor: Assistance Publique - Hôpitaux de Paris
Lupus Nephritis · Membranous Nephropathy
France
Early Detection of Triple Negative Breast Cancer Relapse (CUPCAKE)Recruiting
NCT06225505NAUpdated Jul 23, 2026
Sponsor: Institut Curie
Triple Negative Breast Cancer
France
BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural MesotheliomaCompleted
NCT03762018Phase 3Updated Jul 22, 2026
Sponsor: ETOP IBCSG Partners Foundation
Pleural Mesothelioma Malignant Advanced
Belgium, France, Italy, Spain, Switzerland +1 more
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's DiseaseRecruiting
NCT06819878Phase 3Updated Jul 22, 2026
Sponsor: Hoffmann-La Roche
Moderately to Severely Active Crohns Disease
United States, Argentina, Australia, Austria, Belgium +33 more
A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMDRecruiting
NCT06847542Phase 3Updated Jul 22, 2026
Sponsor: Hoffmann-La Roche
Neovascular Age-related Macular Degeneration
Austria, Czechia, Denmark, France, Germany +8 more
Impact of Microglial Activation on Synaptic Density in Alzheimer's DiseaseActive Not Recruiting
NCT05911178NAUpdated Jul 22, 2026
Sponsor: Centre Hospitalier St Anne
Alzheimer Disease
France

3,153 studies found