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5,213 studies for “Merck”

Safety and Immunogenicity of V540B in Healthy Adults (V540B-002).Recruiting
NCT06623409Phase 1Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
United States
Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate CancerRecruiting
NCT05766371Phase 2Updated Sep 10, 2026
Sponsor: University of California, San Francisco
Castrate Resistant Prostate Cancer · Metastatic Castration-resistant Prostate Cancer · Prostate Cancer · Prostate Carcinoma
United States
Study of Pimicotinib in Japanese Participants With Tenosynovial Giant Cell Tumor (TGCT) (J-MANEUVER)Recruiting
NCT07499362Phase 2Updated Sep 10, 2026
Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Tenosynovial Giant Cell Tumor
Japan
Parents' HPV StoriesNot Yet Recruiting
NCT06704308NAUpdated Sep 10, 2026
Sponsor: Anne E Ray
HPV Vaccination
United States
Study of Cryoablation and Nirogacestat for Desmoid TumorRecruiting
NCT05949099Phase 2Updated Sep 10, 2026
Sponsor: Nam Bui
Desmoid Tumor
United States
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)Recruiting
NCT03486873Phase 3Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Solid Tumors · Hematologic Malignancies
United States, Argentina, Australia, Austria, Belgium +46 more
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)Recruiting
NCT06818643Phase 1, Phase 2Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Advanced Solid Tumors · Malignant Neoplasm
United States, Chile, China, France, Israel +7 more
Pembrolizumab and Lenvatinib in Advanced Cervical CancerRecruiting
NCT04865887Phase 2Updated Sep 10, 2026
Sponsor: Georgetown University
Cervical Cancer · Metastatic Cervical Cancer
United States
A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)Terminated
NCT05665595Phase 3Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Melanoma
United States, Argentina, Australia, Austria, Belgium +21 more
Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0)Not Yet Recruiting
NCT07513324Phase 2Updated Sep 10, 2026
Sponsor: Dana-Farber Cancer Institute
HPV-positive Oropharyngeal Squamous Cell Carcinoma · Oropharyngeal Squamous Cell Carcinoma
United States
A Study to Evaluate V181 Dengue Vaccine in Healthy Participants 2 to 17 Years of Age (V181-005/MOBILIZE-1)Recruiting
NCT07013487Phase 3Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
Indonesia, Malaysia, Philippines, Puerto Rico, Singapore +2 more
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)Active Not Recruiting
NCT04624204Phase 3Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Small Cell Lung Cancer
United States, Australia, Belgium, Bulgaria, Canada +20 more
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)Recruiting
NCT06797635Phase 2Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Breast Neoplasms · Breast Cancer
United States, South Korea, Spain, Taiwan
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)Recruiting
NCT06780111Phase 1, Phase 2Updated Sep 10, 2026
Sponsor: Merck Sharp & Dohme LLC
Esophageal Squamous Cell Carcinoma
United States, Brazil, Chile, China, Czechia +11 more
Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid CancerActive Not Recruiting
NCT05119296Phase 2Updated Sep 9, 2026
Sponsor: Saad A Khan
Thyroid Cancer
United States
Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRCActive Not Recruiting
NCT06578559Phase 2Updated Sep 9, 2026
Sponsor: Gruppo Oncologico del Nord-Ovest
Colorectal Cancer
Italy
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)Recruiting
NCT07266831Phase 2, Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
United States, Argentina, Canada, Chile, France +4 more
M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid TumorsRecruiting
NCT07166601Phase 1Updated Sep 9, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Advanced Solid Tumor
United States, Canada, Japan
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)Recruiting
NCT06780137Phase 1, Phase 2Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Small Cell Lung Cancer
United States, Argentina, Australia, Chile, China +7 more
Study of M5049 in DM and PM Participants (NEPTUNIA)Terminated
NCT05650567Phase 2Updated Sep 9, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Dermatomyositis · Polymyositis
United States, Czechia, Greece, Italy, Poland +2 more
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)Recruiting
NCT07133633Phase 2Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Radiographic Axial Spondyloarthritis
United States, Brazil, Canada, Chile, China +9 more
A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)Recruiting
NCT07646860Phase 2Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Pulmonary Arterial Hypertension
Japan
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)Recruiting
NCT07463183Phase 2Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Colitis Ulcerative · Ulcerative Colitis
United States, Canada, Colombia, France, Greece +4 more
A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)Recruiting
NCT07614984Phase 2Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Lipoprotein(a)
United States, Japan
M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)Active Not Recruiting
NCT06421935Phase 1Updated Sep 9, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Advanced Solid Tumor
United States, Australia, Japan, South Korea, Spain

5,213 studies found