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Results for “Merck”

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)Recruiting
NCT06997497Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Colon Adenocarcinoma · Rectal Adenocarcinoma
United States, Argentina, Australia, Brazil, Canada +24 more
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)Recruiting
NCT07190248Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
United States, Argentina, Australia, Austria, Belgium +25 more
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)Recruiting
NCT06651281Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Crohn Disease · Colitis, Ulcerative
United States, Czechia, France, Georgia, Hungary +2 more
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)Recruiting
NCT07199465Phase 1Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Cytomegalovirus Prophylaxis
United States
Anti-Ly6E Exatecan ADC M7437 in Advanced Solid TumorsRecruiting
NCT07360314Phase 1Updated Sep 9, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Advanced Solid Tumors
United States, Canada, Japan, Spain
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)Recruiting
NCT07549412Phase 3Updated Sep 9, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Metastatic Colorectal Cancer
United States, Argentina, Australia, Austria, Belgium +11 more
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)Recruiting
NCT07218029Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Pulmonary Arterial Hypertension
United States, Argentina, Australia, Belgium, Brazil +22 more
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)Recruiting
NCT06667700Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Coronavirus Disease (COVID-19)
United States, Argentina, Brazil, Bulgaria, Colombia +19 more
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)Recruiting
NCT07554339Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
United States, Argentina, Australia, Brazil, China +11 more
Familial Mediterranean Fever and Related Disorders: Genetics and Disease CharacteristicsRecruiting
NCT00001373N/AUpdated Sep 9, 2026
Sponsor: National Human Genome Research Institute (NHGRI)
Familial Mediterranean Fever (FMF) · Autoinflammation · Periodic Fever · Fever
United States
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)Recruiting
NCT06430801Phase 3Updated Sep 9, 2026
Sponsor: Merck Sharp & Dohme LLC
Crohn's Disease
United States, Australia, Austria, Belgium, Brazil +42 more
A Clinical Study of the Effect of MK-2828 on Rosuvastatin or Furosemide in Healthy People (MK-2828-005)Completed
NCT07431866Phase 1Updated Sep 8, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
United States
Anti-GD2 ADC M3554 in Advanced Solid TumorsRecruiting
NCT06641908Phase 1Updated Sep 8, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Advanced Solid Tumor
United States, Belgium, France, Japan, Switzerland +1 more
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid TumorsRecruiting
NCT06172478Phase 2Updated Sep 8, 2026
Sponsor: Daiichi Sankyo
Advanced Solid Tumor · Melanoma · Head and Neck Cancer · Gastric Cancer
United States, Australia, Belgium, Canada, China +11 more
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)Active Not Recruiting
NCT03897881Phase 2Updated Sep 8, 2026
Sponsor: ModernaTX, Inc.
Melanoma
United States, Australia
A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)Completed
NCT07435194Phase 1Updated Sep 8, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
United States
ChariotMS - Cladribine to Halt Deterioration in People With Advanced Multiple SclerosisActive Not Recruiting
NCT04695080Phase 2, Phase 3Updated Sep 8, 2026
Sponsor: Queen Mary University of London
Advanced Multiple Sclerosis · Progressive Multiple Sclerosis
United Kingdom
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)Recruiting
NCT07340827Phase 3Updated Sep 8, 2026
Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Infertility
Japan
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)Recruiting
NCT06345729Phase 3Updated Sep 8, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
United States, Argentina, Australia, Austria, Brazil +22 more
Improving Vaccine Acceptance Through EHR Integrated Patient- and Provider-Facing Decision SupportCompleted
NCT06482450NAUpdated Sep 4, 2026
Sponsor: Johns Hopkins Bloomberg School of Public Health
Vaccine Hesitancy · Vaccine Refusal
United States
A Clinical Study of V503 in Chinese Females Who Have Previously Received a Bivalent Human Papillomavirus (HPV) Vaccine (V503-108)Not Yet Recruiting
NCT07785843Phase 3Updated Sep 4, 2026
Sponsor: Merck Sharp & Dohme LLC
Papillomavirus Infections
A Community Health Education Intervention for Increasing Community-driven Actions to Reduce the Cancer Burden in Western New YorkRecruiting
NCT06681077NAUpdated Sep 4, 2026
Sponsor: Roswell Park Cancer Institute
Healthy
United States
A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian TumorsActive Not Recruiting
NCT04707248Phase 1Updated Sep 4, 2026
Sponsor: Daiichi Sankyo
Renal Cell Carcinoma · Ovarian Tumor
United States, Japan
Phase 2 Trial Of Sacituzumab Tirumotecan For Treatment Of Refractory Metastatic Or Unresectable Squamous Cell Carcinoma Of The Anus/RectumNot Yet Recruiting
NCT07511023Phase 2Updated Sep 4, 2026
Sponsor: M.D. Anderson Cancer Center
Phase 2 · Sacituzumab Tirumotecan · Refractory Metastatic · Unresectable Squamous
United States
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)Recruiting
NCT06925737Phase 3Updated Sep 3, 2026
Sponsor: Merck Sharp & Dohme LLC
Prostate Cancer · Prostatic Neoplasms
United States, Argentina, Australia, Austria, Brazil +30 more

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