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PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence StudyRecruiting
NCT06713616Phase 3Updated Sep 8, 2026
Sponsor: Yale University
Depression
United States
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High RiskRecruiting
NCT07613294Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Atherosclerosis · Cardiovascular Diseases · Lipoprotein(a)
United States, Australia, Czechia, Hungary, Netherlands +2 more
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung CancerRecruiting
NCT06793215Phase 3Updated Sep 8, 2026
Sponsor: Hoffmann-La Roche
Non-Small Cell Lung Cancer · KRAS G12C Lung Cancer
United States, Argentina, Australia, Belgium, Brazil +23 more
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated SarcomasRecruiting
NCT06422806Phase 3Updated Sep 8, 2026
Sponsor: National Cancer Institute (NCI)
Metastatic Dedifferentiated Liposarcoma · Metastatic Undifferentiated Pleomorphic Sarcoma · Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 · Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
United States, Canada, Puerto Rico
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic AdenocarcinomaRecruiting
NCT07562152Phase 3Updated Sep 8, 2026
Sponsor: Immuneering Corporation
Pancreatic Cancer · Pancreatic Cancer Metastatic · PDAC · PDAC - Pancreatic Ductal Adenocarcinoma
United States, Australia
A Study of SHR-1819 Injection in Adolescents With Severe Atopic DermatitisRecruiting
NCT07309055Phase 3Updated Sep 8, 2026
Sponsor: Guangdong Hengrui Pharmaceutical Co., Ltd
Adolescents With Moderate-to-severe Atopic Dermatitis
China
Pivotal Study of N-acetyl-L-leucine for CACNA1ARecruiting
NCT07221292Phase 3Updated Sep 8, 2026
Sponsor: IntraBio Inc
CACNA1A · Spinocerebellar Ataxia Type 6 · Episodic Ataxia Type 2 · Familial Hemiplegic Migraine-1
United States, Austria, Germany, Greece, Italy +2 more
Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary SyndromesRecruiting
NCT07102628Phase 3Updated Sep 8, 2026
Sponsor: Novartis Pharmaceuticals
Acute Coronary Syndrome
Argentina, Australia, Canada, China, France +9 more
A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary FibrosisRecruiting
NCT07201922Phase 3Updated Sep 8, 2026
Sponsor: Boehringer Ingelheim
Familial Pulmonary Fibrosis · Interstitial Lung Abnormalities · Interstitial Lung Diseases
United States, Argentina, Australia, Belgium, Canada +8 more
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast CancerRecruiting
NCT07173751Phase 3Updated Sep 8, 2026
Sponsor: BioNTech SE
Breast Neoplasms
United States, Argentina, Australia, Belgium, Brazil +11 more
A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia AreataRecruiting
NCT05723198Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Areata Alopecia · Alopecia · Hypotrichosis · Hair Diseases
United States, Argentina, Australia, Canada, France +7 more
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or OverweightRecruiting
NCT07353931Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Osteoarthritis · Overweight or Obesity
United States, Argentina, Belgium, Brazil, Canada +9 more
A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan FastingRecruiting
NCT07613307Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Diabetes Mellitus, Type 2 · Diabetes Melletus · Glucose Metabolism Disorders · Metabolic Disorders
India, Saudi Arabia, South Africa, United Arab Emirates
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian CancerRecruiting
NCT07213804Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Ovarian Neoplasms · Fallopian Tube Neoplasms · Peritoneal Neoplasms · Neoplasm Metastasis
United States, Australia, Austria, Belgium, Brazil +22 more
A Study of SHR-1501 Combination With BCG Versus Placebo Combined With BCG in Subjects With Papillary-Only NMIBCRecruiting
NCT07726992Phase 3Updated Sep 8, 2026
Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Papillary-Only Non-muscle-invasive Bladder Cancer
China
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)Recruiting
NCT07076407Phase 3Updated Sep 8, 2026
Sponsor: Xenon Pharmaceuticals Inc.
Major Depressive Disorder
United States, Finland, Germany, Poland, Romania +2 more
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib TherapyRecruiting
NCT07218926Phase 3Updated Sep 8, 2026
Sponsor: GlaxoSmithKline
Gastrointestinal Neoplasms
United States, Australia, Belgium, Brazil, Canada +14 more
Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic AdenocarcinomaRecruiting
NCT07805954Phase 3Updated Sep 8, 2026
Sponsor: Revolution Medicines, Inc.
Pancreatic Cancer · Pancreatic Cancer Metastatic · PDAC · PDAC - Pancreatic Ductal Adenocarcinoma
United States
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly IncretinRecruiting
NCT07392190Phase 3Updated Sep 8, 2026
Sponsor: Eli Lilly and Company
Overweight · Obesity
United States, Australia, Belgium, Brazil, China +9 more
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)Recruiting
NCT07276724Phase 3Updated Sep 8, 2026
Sponsor: Generate Biomedicines
Severe Asthma
United States, Bulgaria, Czechia, Germany, Greece +6 more
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal CancerRecruiting
NCT07228832Phase 3Updated Sep 8, 2026
Sponsor: Summit Therapeutics
Metastatic Colorectal Cancer (CRC)
United States, Belgium, Canada, China, Czechia +9 more
A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe DiseaseRecruiting
NCT07743580Phase 3Updated Sep 8, 2026
Sponsor: Shionogi
SARS-CoV-2
United States, Bulgaria, Japan
Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOCUS-2)Recruiting
NCT07717879Phase 3Updated Sep 8, 2026
Sponsor: Axsome Therapeutics, Inc.
ADHD
United States
A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic DiseasesRecruiting
NCT06806592Phase 3Updated Sep 8, 2026
Sponsor: Boehringer Ingelheim
Interstitial Lung Diseases · Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases
United States, Australia, Austria, China, France +11 more
Total Intravenous Anesthesia and Recurrence Free SurvivalRecruiting
NCT04513808Phase 3Updated Sep 8, 2026
Sponsor: The Cleveland Clinic
Esophageal Cancer
China

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