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Results for “Merck”

Pembrolizumab With Liver-Directed or Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors and Liver MetastasesCompleted
NCT03457948Phase 2Updated Aug 28, 2026
Sponsor: Nicholas Fidelman, MD
Metastatic Malignant Neoplasm in the Liver · Neuroendocrine Neoplasm
United States
Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN LossCompleted
NCT03131908Phase 1, Phase 2Updated Aug 27, 2026
Sponsor: M.D. Anderson Cancer Center
Melanoma and Other Malignant Neoplasms of Skin · Metastatic Melanoma
United States
A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)Not Yet Recruiting
NCT07709000Phase 2Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukaemia · Small Lymphocytic Lymphoma · Hematologic Malignancies
Israel
Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)Completed
NCT04303169Phase 1, Phase 2Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Melanoma
United States, Australia, France, Israel, Italy +1 more
Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)Active Not Recruiting
NCT06456346Phase 3Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Essential Thrombocythemia
United States, Argentina, Australia, Austria, Canada +18 more
Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) in Patients With Selected Advanced or Metastatic Solid TumorsCompleted
NCT05479812Phase 1Updated Aug 27, 2026
Sponsor: Werewolf Therapeutics, Inc.
Metastatic Solid Tumor · Advanced Solid Tumor
United States
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).Recruiting
NCT05947851Phase 3Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Leukemia, Lymphocytic, Chronic, B-Cell · Leukemia, Chronic Lymphocytic · Small-Cell Lymphoma · Lymphoma, Small Lymphocytic
United States, Argentina, Australia, Belgium, Brazil +13 more
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)Recruiting
NCT06136559Phase 3Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
United States, Australia, Belgium, Brazil, Canada +24 more
HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI TherapyActive Not Recruiting
NCT05338970Phase 3Updated Aug 27, 2026
Sponsor: Daiichi Sankyo
Nonsquamous Non-small Cell Lung Cancer · EGFR L858R · EGFR Exon 19 Deletion
United States, Australia, Austria, Belgium, Canada +16 more
Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx CancersCompleted
NCT04943445Phase 2Updated Aug 27, 2026
Sponsor: Latin American Cooperative Oncology Group
Squamous Cell Carcinoma of Larynx
Brazil
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)Recruiting
NCT06623422Phase 3Updated Aug 27, 2026
Sponsor: Merck Sharp & Dohme LLC
Carcinoma, Non-Small-Cell Lung
United States, Argentina, Australia, Belgium, Brazil +26 more
A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)Completed
NCT07528508Phase 1Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
United States
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)Recruiting
NCT07513376Phase 3Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
United States, Australia, Canada, France, Germany +11 more
Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)Completed
NCT03615326Phase 3Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Gastric Neoplasms · Gastroesophageal Junction Adenocarcinoma
United States, Australia, Brazil, Chile, China +15 more
Letermovir for R+ StudyNot Yet Recruiting
NCT07706166Phase 4Updated Aug 26, 2026
Sponsor: University of Wisconsin, Madison
Kidney Transplant · Liver Transplant
United States
A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)Recruiting
NCT06822543Phase 2Updated Aug 26, 2026
Sponsor: Latin American Cooperative Oncology Group
Lung Cancer · Non Small Cell Lung Cancer · Brain Metastases
Brazil
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell CarcinomaRecruiting
NCT06016920Phase 1, Phase 2Updated Aug 26, 2026
Sponsor: Nykode Therapeutics ASA
HPV Positive Oropharyngeal Squamous Cell Carcinoma · HNSCC
France, Germany, Hungary, Norway, Poland +2 more
A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)Recruiting
NCT06833073Phase 2Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Urinary Bladder Neoplasms · Non-Muscle Invasive Bladder Neoplasms · Carcinoma in Situ
United States, Argentina, Australia, Brazil, Canada +14 more
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)Recruiting
NCT07033494Phase 2Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Early Alzheimer's Disease
United States, Argentina, Australia, Belgium, Canada +6 more
Prospective Trial Assessing Real World Outcomes Response to Pembro in Black Patients w/ NSCLCRecruiting
NCT06745882Phase 2Updated Aug 26, 2026
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Non-small Cell Lung Cancer
United States
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)Active Not Recruiting
NCT05722015Phase 3Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Metastatic Non-small Cell Lung Cancer
United States, Argentina, Brazil, Chile, China +11 more
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan ExtensionActive Not Recruiting
NCT06212752Phase 3Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Metastatic Non-small Cell Lung Cancer
Japan
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and PostpartumTerminated
NCT04518228N/AUpdated Aug 26, 2026
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
HIV · Tuberculosis
United States, Brazil, India, Kenya, Puerto Rico +3 more
A Clinical Trial of Enlicitide (MK-0616) Formulations in Healthy Participants (MK-0616-044)Recruiting
NCT07776665Phase 1Updated Aug 26, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
United States
pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate CancerActive Not Recruiting
NCT04090528Phase 2Updated Aug 26, 2026
Sponsor: University of Wisconsin, Madison
Castration-resistant Prostate Cancer · Metastatic Cancer · Prostate Cancer
United States

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