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Results for “Roche”

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)Active Not Recruiting
NCT03148418Phase 3Updated Jul 10, 2026
Sponsor: Hoffmann-La Roche
Cancer
United States, Argentina, Australia, Austria, Belgium +27 more
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) EncephalitisActive Not Recruiting
NCT05503264Phase 3Updated Jul 10, 2026
Sponsor: Hoffmann-La Roche
NMDAR Autoimmune Encephalitis · LGI1 Autoimmune Encephalitis
United States, Argentina, Brazil, China, Czechia +12 more
A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast CancerRecruiting
NCT07347600N/AUpdated Jul 10, 2026
Sponsor: Hoffmann-La Roche
Locally Advanced Breast Cancer · Metastatic Breast Cancer
China
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)Not Yet Recruiting
NCT07541170Phase 3Updated Jul 10, 2026
Sponsor: Hoffmann-La Roche
Non-small Cell Lung Cancer
A Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in Participants With Diabetic Macular Edema (DME) Compared With Intravitreal Ranibizumab; A Substudy to Evaluate the Safety of Re-implanting the PDS With Ranibizumab in Participants With DMEActive Not Recruiting
NCT04108156Phase 3Updated Jul 10, 2026
Sponsor: Hoffmann-La Roche
Diabetic Macular Edema
United States
A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand DiseaseRecruiting
NCT06998524Phase 3Updated Jul 10, 2026
Sponsor: Hoffmann-La Roche
Von Willebrand Disease, Type 3
United States, Belgium, Canada, Colombia, France +9 more
A Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)Recruiting
NCT05199688Phase 3Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Neuromyelitis Optica Spectrum Disorder · NMOSD
United States, Argentina, China, France, Italy +4 more
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or ObesityActive Not Recruiting
NCT07137585Phase 1Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Type 2 Diabetes Mellitus · Obesity · Overweight
Germany
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Enicepatide in Generally Healthy Adult Chinese ParticipantsRecruiting
NCT07626515Phase 1Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Healthy Participants
China
A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular AtrophyActive Not Recruiting
NCT03779334Phase 2Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Muscular Atrophy, Spinal
United States, Australia, Belgium, Brazil, Poland +2 more
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-PositiveRecruiting
NCT07413939Phase 2, Phase 3Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
HER2-positive Breast Cancer
Argentina, Australia, Austria, Belgium, Canada +16 more
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)Recruiting
NCT07161258Phase 2Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Relapsing Multiple Sclerosis
Argentina, Brazil, Mexico, Poland, Portugal +2 more
A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene TherapyRecruiting
NCT05861999Phase 4Updated Jul 9, 2026
Sponsor: Hoffmann-La Roche
Muscular Atrophy, Spinal
United States, Germany, Israel, Poland, Qatar +1 more
Combination of Atezolizumab With Dendritic Cell Vaccine in Patients With Lung CancerCompleted
NCT04487756Phase 1, Phase 2Updated Jul 8, 2026
Sponsor: Instituto Oncológico Dr Rosell
Extensive-stage Small Cell Lung Cancer
Spain
A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple MyelomaRecruiting
NCT06934044Phase 1Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Multiple Myeloma
China
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung CancerRecruiting
NCT06793215Phase 3Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Non-Small Cell Lung Cancer · KRAS G12C Lung Cancer
United States, Argentina, Australia, Belgium, Brazil +23 more
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast CancerRecruiting
NCT07368998Phase 2Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Breast Cancer
United States, Argentina, Australia, Belgium, Mexico +3 more
A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia ARecruiting
NCT07416604Phase 3Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Hemophilia A
United States, Israel, Japan, Spain
A Study to Assess Treatment Patterns and Treatment Adherence in Early HER2-positive Breast Cancer Participants After Treatment DecentralizationRecruiting
NCT07527741N/AUpdated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Early-stage HER2+ Breast Cancer
Serbia
Sixth Generation High-sensitivity Cardiac Troponin T for the Early Rule Out of Myocardial Infarction: a Controlled Before and After StudyRecruiting
NCT07636642NAUpdated Jul 7, 2026
Sponsor: University of Edinburgh
Myocardial Infarction
United Kingdom
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's DiseaseRecruiting
NCT07170150Phase 3Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Alzheimers Disease
United States, Argentina, Australia, Brazil, Canada +11 more
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous NephropathyActive Not Recruiting
NCT04629248Phase 3Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Primary Membranous Nephropathy
United States, Argentina, Brazil, China, France +6 more
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or OverweightRecruiting
NCT07499050Phase 1Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Healthy Volunteers · Overweight or Obesity
China
A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD)Recruiting
NCT05562947Phase 3Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Neovascular Age-related Macular Degeneration · nAMD
China
A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)Recruiting
NCT06534983Phase 2Updated Jul 7, 2026
Sponsor: Hoffmann-La Roche
Muscle-invasive Urothelial Carcinoma
United States, Argentina, Australia, Belgium, Brazil +15 more

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