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Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular DystrophyRecruiting
NCT05933057Phase 3Updated Jul 24, 2026
Sponsor: Italfarmaco
Duchenne Muscular Dystrophy
Belgium, Canada, Czechia, France, Germany +7 more
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD MutationsRecruiting
NCT07195695Phase 3Updated Jul 24, 2026
Sponsor: Boehringer Ingelheim
Non-small Cell Lung Cancer
United States, Argentina, Australia, Austria, Belgium +23 more
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)Recruiting
NCT07007065Phase 3Updated Jul 24, 2026
Sponsor: AbbVie
Neovascular Age-related Macular Degeneration
United States, Austria, Belgium, Bulgaria, Canada +12 more
Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric PatientsRecruiting
NCT06706674Phase 3Updated Jul 24, 2026
Sponsor: Intra-Cellular Therapies, Inc.
Irritability Associated With Autism Spectrum Disorder
United States
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)Recruiting
NCT03486873Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Solid Tumors · Hematologic Malignancies
United States, Argentina, Australia, Austria, Belgium +46 more
Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal CancerRecruiting
NCT07392892Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: Pfizer
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma · Metastatic Gastric Cancer · Gastroesophageal Junction Cancer · Esophageal Adenocarcinoma
United States, China, Israel, Japan, Puerto Rico +1 more
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)Recruiting
NCT07340827Phase 3Updated Jul 24, 2026
Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Infertility
Japan
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)Recruiting
NCT06568367Phase 3Updated Jul 24, 2026
Sponsor: Axsome Therapeutics, Inc.
Excessive Sleepiness · Shift-work Disorder
United States, Canada
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMRecruiting
NCT05902169Phase 3Updated Jul 24, 2026
Sponsor: CarThera
Glioblastoma · Recurrent Glioblastoma · GBM
United States, Austria, Belgium, Denmark, France +6 more
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)Recruiting
NCT07549412Phase 3Updated Jul 24, 2026
Sponsor: EMD Serono Research & Development Institute, Inc.
Metastatic Colorectal Cancer
United States, Australia, Canada, Japan, South Korea +1 more
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)Recruiting
NCT06136624Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Prostate Cancer Metastatic
United States, Argentina, Australia, Austria, Brazil +31 more
A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)Recruiting
NCT07196501Phase 3Updated Jul 24, 2026
Sponsor: Neurocrine Biosciences
Major Depressive Disorder
United States, Australia, Bulgaria, Canada, Estonia +6 more
Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC TrialRecruiting
NCT07388524Phase 3Updated Jul 24, 2026
Sponsor: National Cancer Institute (NCI)
Lung Non-Small Cell Carcinoma
United States
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)Recruiting
NCT07058077Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Heterozygous Familial Hypercholesterolemia (HeFH)
United States, Australia, Belgium, Brazil, Chile +10 more
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)Recruiting
NCT06997497Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Colon Adenocarcinoma · Rectal Adenocarcinoma
United States, Argentina, Australia, Brazil, Canada +23 more
Phase III Study of HRS-5635 in Nucleos(t)Ide Analogue-suppressed HBeAg-negative Patients With Chronic Hepatitis BRecruiting
NCT07606950Phase 3Updated Jul 24, 2026
Sponsor: Fujian Shengdi Pharmaceutical Co., Ltd.
Nucleos(t)Ide Analogue-suppressed HBeAg-negative Patients With Chronic Hepatitis B
China
Vorasidenib Maintenance for IDH Mutant AstrocytomaRecruiting
NCT06809322Phase 3Updated Jul 24, 2026
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
IDH-mutant Grade 2 or 3 Astrocytoma
Austria, Belgium, Czechia, France, Germany +5 more
Phase IIb Clinical Trial to Evaluate the Efficacy and Safety of VG081821AC Tablets in Patients With Early to Mid-stage Parkinson's DiseaseRecruiting
NCT07725562Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: Zhejiang Vimgreen Pharmaceuticals, Ltd.
Parkinson Disease (PD)
China
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease StudiesRecruiting
NCT07177352Phase 3Updated Jul 24, 2026
Sponsor: Hoffmann-La Roche
Alzheimers Disease
United States, Argentina, Australia, Brazil, Canada +9 more
Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With AchondroplasiaRecruiting
NCT07441876Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: BioMarin Pharmaceutical
Achondroplasia
United States, Australia, Canada, Italy, Japan +4 more
A Study to Evaluate Atumelnant in Adults With Congenital Adrenal HyperplasiaRecruiting
NCT07144163Phase 3Updated Jul 24, 2026
Sponsor: Crinetics Pharmaceuticals Inc.
Congenital Adrenal Hyperplasia · Classic Congenital Adrenal Hyperplasia
United States, Argentina, Australia, Austria, Brazil +8 more
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using SolriamfetolRecruiting
NCT07484217Phase 3Updated Jul 24, 2026
Sponsor: Axsome Therapeutics, Inc.
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
United States
A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally Advanced or Metastatic Biliary Tract Cancer After Failure of Platinum-based Chemotherapy(PANKU-BTC01)Recruiting
NCT07582315Phase 3Updated Jul 24, 2026
Sponsor: Sichuan Baili Pharmaceutical Co., Ltd.
Biliary Tract Cancer
China
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial HypercholesterolemiaRecruiting
NCT06597006Phase 3Updated Jul 24, 2026
Sponsor: Novartis Pharmaceuticals
Familial Hypercholesterolemia - Homozygous
United States, Austria, China, Germany, Greece +6 more
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)Recruiting
NCT07496567Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: EyeBiotech Ltd.
Macular Degeneration · Age-Related Macular Degeneration · Choroidal Neovascularization · Wet Macular Degeneration
United States, Brazil, Colombia, Czechia, France +3 more

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