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Shortened Regimen for Drug-susceptible TB in ChildrenRecruiting
NCT06253715Phase 3Updated Jul 24, 2026
Sponsor: Johns Hopkins University
Tuberculosis · Tuberculosis, Pulmonary · Tuberculosis, Lymph Node · Mycobacterium Tuberculosis
India, Indonesia, Mozambique, South Africa, Uganda +2 more
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF TherapyRecruiting
NCT05889182Phase 3Updated Jul 24, 2026
Sponsor: AbbVie
Hidradenitis Suppurativa
United States, Argentina, Australia, Austria, Belgium +32 more
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).Recruiting
NCT05947851Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Leukemia, Lymphocytic, Chronic, B-Cell · Leukemia, Chronic Lymphocytic · Small-Cell Lymphoma · Lymphoma, Small Lymphocytic
United States, Argentina, Australia, Belgium, Brazil +13 more
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)Recruiting
NCT06966401Phase 3Updated Jul 24, 2026
Sponsor: Neurocrine Biosciences
Major Depressive Disorder
United States, Belgium, Bulgaria, Canada, Croatia +15 more
A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic AcidosisRecruiting
NCT07355062Phase 3Updated Jul 24, 2026
Sponsor: Renibus Therapeutics, Inc.
CKD · Metabolic Acidosis
United States
BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic DiseaseRecruiting
NCT07492641Phase 3Updated Jul 24, 2026
Sponsor: BeOne Medicines
HR+/HER2- Breast Cancer
United States, Australia, China, Japan, Malaysia +2 more
A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)Recruiting
NCT06929273Phase 3Updated Jul 24, 2026
Sponsor: Bristol-Myers Squibb
Bipolar Disorder Type I With Mania
United States, Argentina, Australia, Bulgaria, China +15 more
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)Recruiting
NCT07431827Phase 3Updated Jul 24, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
Argentina, Australia, Canada, China, France +8 more
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin AnalogsRecruiting
NCT06930625Phase 3Updated Jul 24, 2026
Sponsor: Debiopharm International SA
Acromegaly
United States, Austria, Belgium, Brazil, Bulgaria +16 more
Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular LymphomaRecruiting
NCT06337318Phase 3Updated Jul 24, 2026
Sponsor: National Cancer Institute (NCI)
Classic Follicular Lymphoma · Follicular Lymphoma With Unusual Cytological Features
United States
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's DiseaseRecruiting
NCT04528082Phase 3Updated Jul 24, 2026
Sponsor: Amgen
Behçet Disease
France, Greece, Israel, Italy, Spain +3 more
A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy FailureRecruiting
NCT07606599Phase 3Updated Jul 24, 2026
Sponsor: Sichuan Baili Pharmaceutical Co., Ltd.
Biliary Tract Cancer
China
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)Recruiting
NCT06439082Phase 3Updated Jul 24, 2026
Sponsor: Novartis Pharmaceuticals
Sickle Cell Disease
United States, Brazil, Colombia, Kenya, Uganda
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR TrialRecruiting
NCT04402788Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: National Cancer Institute (NCI)
Extensive Stage Lung Small Cell Carcinoma
United States
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research DesignRecruiting
NCT07398417Phase 3Updated Jul 24, 2026
Sponsor: Axsome Therapeutics, Inc.
Fibromyalgia
United States
A Study of Nipocalimab in Reducing the Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)Recruiting
NCT06449651Phase 3Updated Jul 24, 2026
Sponsor: Janssen Research & Development, LLC
Thrombocytopenia, Neonatal Alloimmune
Belgium, Brazil, France, Hungary, Israel +7 more
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple SclerosisRecruiting
NCT07299019Phase 3Updated Jul 24, 2026
Sponsor: Zenas BioPharma (USA), LLC
Secondary Progressive Multiple Sclerosis
United States, Poland
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPCRecruiting
NCT06855277Phase 3Updated Jul 24, 2026
Sponsor: Novartis Pharmaceuticals
Prostate Cancer
United States, Australia, Brazil, China, Hong Kong +6 more
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE TrialRecruiting
NCT06203600Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: National Cancer Institute (NCI)
Advanced Esophageal Adenocarcinoma · Advanced Gastric Adenocarcinoma · Advanced Gastroesophageal Junction Adenocarcinoma · Clinical Stage II Esophageal Adenocarcinoma AJCC v8
United States
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or ObesityRecruiting
NCT07037433Phase 3Updated Jul 24, 2026
Sponsor: Amgen
Atherosclerotic Cardiovascular Disease · Overweight · Obesity
United States, Argentina, Australia, Austria, Belgium +31 more
Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)Recruiting
NCT05722938Phase 3Updated Jul 24, 2026
Sponsor: Biotest
Community-acquired Pneumonia
United States, Argentina, Australia, Austria, Belgium +13 more
A Study in Pediatric Participants With Congenital Adrenal Hyperplasia (Balance-CAH)Recruiting
NCT07159841Phase 2, Phase 3Updated Jul 24, 2026
Sponsor: Crinetics Pharmaceuticals Inc.
Congenital Adrenal Hyperplasia · Classic Congenital Adrenal Hyperplasia
United States, Argentina, Australia, Belgium, Brazil +6 more
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1Recruiting
NCT07563881Phase 3Updated Jul 24, 2026
Sponsor: Rapport Therapeutics Inc.
Focal Seizure · Epilepsy · Focal Epilepsy
United States
A Study Investigating Intravenous Human Normal Immunoglobulin 10% in Adults With Chronic Immune Thrombocytopenia (ITP)Recruiting
NCT07059000Phase 3Updated Jul 24, 2026
Sponsor: Kedrion S.p.A.
Chronic Primary Immune Thrombocytopenia (ITP)
United States, Czechia, Germany, Italy, Romania +3 more
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade GliomaRecruiting
NCT04166409Phase 3Updated Jul 24, 2026
Sponsor: National Cancer Institute (NCI)
Low Grade Astrocytoma · Low Grade Glioma · Metastatic Low Grade Astrocytoma · Metastatic Low Grade Glioma
United States, Canada, Puerto Rico

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